Cyclone separators work by utilizing the momentum of incoming particulates to mechanically separate materials of different densities--similar to how a centrifuge works. For woodworking dust collection, the inbound air velocity is used to literally spin the dust out of the air.
Check out this list of the DOs and DON'Ts of designing a ductwork layout. Please note that many of these rules do not apply to high-pressure systems such as the Supercell. You can learn more about designing ductwork for the Supercell in our Supercell Ducting Guide.